2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12707A
    Piribedil dihydrochloride 1451048-94-4 98%
    Piribedil dihydrochloride is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil dihydrochloride is also a α2-adrenoceptors antagonist. Piribedil dihydrochloride can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil dihydrochloride has the potential for the research of parkinson's disease, circulatory disorders, cancers.
    Piribedil dihydrochloride
  • HY-12707C
    Piribedil hydrochloride 78213-63-5 98%
    Piribedil hydrochloride is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil hydrochloride is also a α2-adrenoceptors antagonist. Piribedil hydrochloride can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil hydrochloride has the potential for the research of parkinson's disease, circulatory disorders, cancers.
    Piribedil hydrochloride
  • HY-127086
    Dicarbine 17411-19-7 98%
    Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used in the schizophrenia and alcoholic psychosis studies.
    Dicarbine
  • HY-127119
    Benanserin hydrochloride 525-02-0
    Benanserin hydrochloride is a serotonin antagonist with psychopharmacological activity. Benanserin hydrochloride can be used to study specific behavioral manifestations in monitoring systems for drug effects. The effects of Benanserin hydrochloride can be sensitively and effectively assessed, for example, by measuring muscle movement capacity and reaction time. Benanserin hydrochloride is suitable for monitoring specific muscle physiological changes. The biological activity of Benanserin hydrochloride can provide reproducible bioassay parameters for experiments.
    Benanserin hydrochloride
  • HY-127120
    Timiperone 57648-21-2 98%
    Timiperone has a strong affinity for cerebral dopamine D2 receptor. Timiperone has antipsychotic activity, and inhibits stereotyped behaviour. Timiperone can be used for research of schizophrenia.
    Timiperone
  • HY-127128
    Flestolol sulfate 88844-73-9 98%
    Flestolol (ACC-9089) sulfate is a competitive, ultra-short-acting beta-adrenergic blocking agent. Flestolol sulfate shows a half-life of approximately 6.5 minutes. Flestolol sulfate has the potential for the research of chest pain.
    Flestolol sulfate
  • HY-127144
    α-Saxitoxinol 75420-34-7 98%
    α-Saxitoxinol is an epimer of Dihydtosaxitoxin and a derivative of saxitoxin. α-Saxitoxinol represents approximately 3.7% of the biological activity of Saxitoxin (a neurotoxin).
    α-Saxitoxinol
  • HY-127151
    R-(-)-Phencynonate hydrochloride 861655-73-4 98%
    Levophencynonate is a muscarinic receptor antagonist with anticholinergic activity. The biological activity of levophencynonate makes it a key target for the determination of its concentration in human plasma in medical research. Levophencynonate was analyzed by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and showed good specificity and linearity.
    R-(-)-Phencynonate hydrochloride
  • HY-127165
    Velnacrine 124027-47-0 98%
    Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg.
    Velnacrine
  • HY-12751S
    Trimethobenzamide-d6 98%
    Trimethobenzamide-d6 is deuterium labeled Trimethobenzamide. Trimethobenzamide is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
    Trimethobenzamide-d6
  • HY-12769R
    Mebeverine acid (Standard) 475203-77-1
    Aleuritic acid (Standard) is the analytical standard of Aleuritic acid. This product is intended for research and analytical applications. Aleuritic acid ((±)-erythro-Aleuritic acid) is a major ingredient in Croton crassifolius Geisel. and used in the perfumery industry.
    Mebeverine acid (Standard)
  • HY-12769S
    Mebeverine acid-d5 2070015-30-2 98%
    Mebeverine acid-d5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
    Mebeverine acid-d5
  • HY-12770R
    Mebeverine alcohol (Standard) 14367-47-6
    Mebeverine alcohol (Standard) is an analytical standard for Mebeverine alcohol. This product is intended for research and analytical applications. Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of Chloramphenicol (HY-B0239) and Lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis.
    Mebeverine alcohol (Standard)
  • HY-12770S
    Mebeverine alcohol-d5 2070015-15-3 ≥98.0%
    Mebeverine alcohol-d5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.
    Mebeverine alcohol-d5
  • HY-12771S
    O-Desmethyl Mebeverine acid-d5 1329488-46-1 98.45%
    O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d5
  • HY-128038
    N-Desmethyl-loperamide 66164-07-6 98%
    N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a Ki value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein.
    N-Desmethyl-loperamide
  • HY-128040
    Virodhamine hydrochloride 443129-35-9 98%
    Virodhamine (hydrochloride) is a cannabinoid CB1 receptor partial agonist and cannabinoid CB2 receptor full agonist.
    Virodhamine hydrochloride
  • HY-128386
    Cinitapride monotartrate 1207859-16-2 98%
    Cinitapride monotartrate is a 5-HT1A and 5-HT4 agonist. Cinitapride monotartrate is also a 5-HT2A and D2 antagonist. Cinitapride monotartrate can be used for the research of functional dyspepsia.
    Cinitapride monotartrate
  • HY-128418
    Benzonatate (PEGn) 32760-16-0 98%
    Benzonatate (PEGn) is a unique non-narcotic antitussive agent that has sodium channel-blocking properties and anesthetic effects on the respiratory stretch receptors.
    Benzonatate (PEGn)
  • HY-128420
    Lobeline sulfate 134-64-5 98%
    Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation.
    Lobeline sulfate
Cat. No. Product Name / Synonyms Application Reactivity